The 23rd Annual GCRF Walk for A Cure
will be held:
New York: September 22, 2024
Rockland Lake Park, Congers, New York

San Jose: October 27, 2024
Almaden Lake Park, San Jose, CA

The Team Turano 8th Annual GCRF Fundraiser will be bigger & better than ever before! 
The Turano Family’s GCRF Fundraiser will be held on September 20, 2024
at the Hanover Manor in East Hanover, NJ.

Watch for more details for all three of these GCRf Event Fundraisers!

Click Here For Photos of The 2023 GCRF NY Walk For A Cure Event

Immune and Molecular Therapy of Gastrointestinal Stromal Tumor/ DeMatteo Lab 2023

Ronald P. DeMatteo MD

GIST is the most common human sarcoma, and approximately 85% of these tumors are attributable to a mutation in either KIT or PDGFRA genes. Imatinib mesylate is a tyrosine kinase inhibitor (TKI) that targets both of these genes and is effective in nearly 80% of patients with GIST. The advent of tyrosine kinase inhibitors has increased the median survival from 1 year to over 5 years. Despite this success, imatinib and the other tyrosine kinase inhibitors are not curative even in patients who respond, and many GISTs develop resistance to these drugs, necessitating further therapeutic approaches. Our lab has recently focused on discovering alternative approaches that may increase the efficacy of these tyrosine kinase inhibitors with combination therapy.

Download the full report here.

Understanding the molecular determinants of GIST pathogenesis and novel therapeutics development in GIST

Ping Chi MD, PhD
Memorial Sloan Kettering Cancer Center


Gastrointestinal stromal tumor (GIST) is a rare type of cancer that affects approximately 40,000 patients with an annual incidence of 5,000 cases in the US. It arises from the “pacemaker” cells of the gastrointestinal tract and is mainly characterized by activating mutations in KIT or PDGFRA receptor tyrosine kinases. Despite the initial clinical success of imatinib that targets mutant KIT/PDGFRA, nearly all advanced GIST patients develop imatinib-resistance and eventually die of their disease. It is critical to gain a better understanding of the pathogenesis of GIST to dissect the molecular underpinning of aggressive and metastatic behaviors and to develop novel treatment strategies that enhance first-line imatinib therapy and target and/or prevent imatinib-resistance.

Antonescu Research Lab Synopsis: Proposal for 2023-2024 Funding

Cristina R. Antonescu, MD, Memorial Sloan Kettering Cancer Center


Current risk stratification schemes in gastrointestinal stromal tumor (GIST) have been defined in the pre-imatinib era and rely solely on clinicopathologic metrics: tumor site, tumor size, and mitotic activity. These risk models have performed inconsistently in differentiating potentially aggressive from indolent clinical behavior, offering limited guidance on adjuvant therapy. Additional significant limitations of the current prognostication include the lack of integrated molecular biomarkers and not accounting for the imatinib sensitivity of the primary GIST genotype.


Dr. Jon Trent, MD, PhD, and staff for GIST Cancer Research at the University of Miami, Sylvester Comprehensive Cancer Center has been exploring the use of a new medicine for GIST called Procaspase Activating Compound (PAC)-1. PAC-1 is designed to make other drugs more effective.

During the past 10 years, Sylvester Comprehensive Cancer Center’s Sarcoma Program has developed into the largest sarcoma center in the southeastern United States. With more than 20 dedicated, multidisciplinary, board-certified sarcoma doctors on staff, Sylvester serves approximately 900 new patients per year.

Download the pdf of Dr. Trent's Impact Report August 2022 for Gastrointestinal Stromal Tumor Research.
Impact 2022 Sarcoma_GIST

Why Second Opinions Matter for Sarcoma

Not only do Fox Chase physicians have extensive experience in diagnosing and treating sarcomas, but they head panels of experts tasked with writing and updating sarcoma treatment guidelines that are used both nationally and globally. They also work with other world-renowned experts to conduct clinical trials, both for early and advanced stage sarcomas.

“When we see a patient with sarcoma, we think about how to best treat them as a team,” said Margaret von Mehren, MD, Chief of the Division of Sarcoma Oncology at Fox Chase. “Our program includes specialists in sarcoma medical oncology, surgical oncology, orthopedic surgical oncology, radiation oncology, radiology and pathology who review tumor biopsies and imaging to determine the best possible treatment for each case.”

Tania’s Story and the Formation of the GIST Cancer Research Fund

“I started with just a little website,” Tania says. “I went on local radio. I went to our local paper and told them my story.” In 2001, she held her first walkathon and raised $23,000. In 2018, the foundation has raised more than $10 million dollars and every penny has gone to GIST Cancer Research.

GCRF Proclamation

United States Senator, Charles “Chuck” Schumer graciously acknowledged the GIST Cancer Research Fund with a proclamation for the importance of the numerous contributions that the GIST Cancer Research Fund and the Walk For A Cure has made to find a cure for GIST Cancer.


Cameron Gow

January 14, 1957 - February 19, 2018


A Message of Hope

GCRF received a special letter from the spouse of a GIST Cancer patient giving us all hope.

Everything You Need To Know About GIST Cancer • Cancer.net

The best cancer care starts with the best cancer information. With nearly 50,000 members in 170 countries who are leaders in advancing cancer care, the American Society of Clinical Oncology (ASCO) is the voice of the world’s cancer physicians. ASCO’s patient information website Cancer.Net brings the expertise and resources of ASCO to people living with cancer and those who care for and care about them. This website provides a wealth of information on gastrointestinal stromal tumor (GIST) cancer. Click the button below for more information on this GIST Cancer website.

GIST Cancer Research Fund Proposal for 2023-2024







Michael Heinrich, M.D., and Christopher Corless, M.D., Ph.D.

Understanding mechanisms of resistance

Recently, two new drugs (avapritinib, ripretinib) have become approved for treatment of advanced GIST. These drugs provide new therapy options, but already we have seen clinical resistance to these new drugs. In order to continue to improve treatments, we need to understand the ways by which GIST cells can overcome these new “wonder drugs”. We have established new technologies and cell lines to determine the mechanisms of resistance to these agents. Using our improved technologies, we can “fast forward” our experiments to more rapidly discover new resistance mutations. In addition to determining resistance mechanisms for these two new agents, we will also study resistance mechanisms to new drugs that will be tested in clinical studies in 2023-2024: CGT9486, THE-630, IDRX42, NB003, and the combination of CGT9486 + sunitinib. We have already completed pilot experiments with THE-630, IDRX42, NB003, and CGT9486

2024 GIST Education Conference and Luncheon, OHSU Knight Cancer Institute

The 2024 GIST Education Conference and Luncheon will be held on October 24, 2024 at The OHSU Knight Cancer Institute in Portland, Oregon.  Speakers to be announced. An official invitation will be posted later this year. The 2023 GIST Education Conference can be viewed below:

Click Here To View Presentation


Welcome to the Heinrich-Corless Research Lab

A look behind the scenes in the lab of Dr. Michael Heinrich and Dr. Chris Corless at the Oregon Health & Science Center/Knight Cancer Institute. Here is an overview of the current research being performed to find a cure for GIST Cancer.

Thank you to Tania, Robert and everyone with the GIST Cancer Research Fund for your loyal support of the OHSU Knight Cancer Institute in our mission to end cancer as we know it. I am inspired and humbled by your commitment to us. Thank you again.”

Brian Druker, M.D., Director, OHSU Knight Cancer Institute

Looking For A GIST Cancer Doctor?

GIST is a rare form of cancer that most doctors misdiagnose or are not familiar with the appropriate treatment. If you or a loved-one is diagnosed with GIST, getting in touch with a physician who specializes in GIST Cancer is of utmost importance. These doctors and researchers deal with this disease on a daily basis and can help guide you to the right treatment.

In addition to the GIST Cancer Research Team of physicians, researchers and nurses, the following link will put you in touch with domestic and international GIST Cancer specialists.

Memorial Sloan Kettering Cancer Center Honors The GCRF On Its Donor Wall in New York City

In 2012, The GIST Cancer Research Fund and Robert and Tania Stutman were honored by Memorial Sloan Kettering Cancer Center for GCRF’s generous donations given for GIST Cancer Research. Their names were etched into MSKCC’s donor wall for posterity. For almost twenty years, The GIST Cancer Research Fund has been tirelessly fighting to raise funds to eradicate this deadly disease with no staff, corporate headquarters or overhead. Since 2002, the foundation has raised more than $10 million and MSK has been the beneficiary of $1.6 million. Events including walkathons, 1,000-mile Cycling for a Cure bike rides, golf outings and galas now span the nation. (Other GCRF beneficiaries include Fox Chase, Brigham and Women’s Hospital in Boston, Oregon Health Sciences University Cancer Institute, and MD Anderson Cancer Center in Houston.) At MSK, the GCRF supports the work of Dr. Antonescu and Dr. Ping Chi.

Robert and Tania Stutman join the generous philantropists including Susan G. Komen, who donate to MSKCC. The GCRF has raised $10 million dollars for GIST Cancer Research and has given 100% of these fund to finding a cure for GIST Cancer. As Tania Stutman said, ‘I’m not only battling for my life, I’m fighting for the lives of others.’”

GIST Cancer Bracelets, Ribbons and T-Shirts Available for Sale!

GCRF has GIST Cancer Bracelets, Ribbons and T-Shirts available for sale. By wearing and displaying them, you are spreading a message and awareness to find a cure for this rare cancer.
Click on the button below to buy today!

Walt "Clyde" Frazier, GCRF's Distinguished Spokesperson

Walt Frazier is a two-time NBA champion with the New York Knicks, a seven-time NBA All-Star and a member of the Basketball Hall of Fame. His retired No. 10 Knicks jersey is hanging in the rafters in Madison Square Garden. The NBA veteran is also known to be the GCRF's very own spokesperson. Walt has attended the GCRF New York Walk For A Cure for 18 years. His loyalty and commitment to GIST Cancer Research is relentless and he always finds the time to "be there" for the GIST Cancer Research Fund in good times and bad. Thank you Walt for all you have done and know that we hold a special place for you in our hearts!

Thank You Team Turano!

The amazing Team Turano, headed by Karen and Angelo Turano and family,
held their 7th Annual Fundraiser for GCRF 7th Annual GCRF Fundraiser
September 22, 2023 at the Hanover Manor, East Hanover, NJ.

It was a tremendous success with over 200 prizes, a 50/50 raffle of $3,000 and delicious food.  Thank you to Team Turano for all of your hard work and dedication to GCRF and raising funds and awareness to find a cure for GIST Cancer.

Click Here For More Team Turano Event Information


In Memory of My Aunt, Stephanie Kalenda

Stephanie (Teta) Kalenda had GIST cancer. Like so many patients, she fought a valiant fight against this disease and yet lost her life.  Her niece, Jamela, decided to start a small fundraiser beginning on July 12, GIST Awareness Day in memory of her Teta, who would have been 64 years old. She was looking for 64 donations. While she didn't make the goal, she still raised over $1700. for GIST Cancer Research. This young woman is making a difference in the fight for a cure of GIST Cancer. She made a stand and took action so that one day, there will be cure of this terrible disease.

One behalf of all of us at GCRF, thank you Jamela! Your Teta will always be remembered and loved.